HYP*MOL colloquium with Guinevere Mathies

On January 10, 2025, the HYP*MOL year began with Dr. Guinevere Mathies from the University of Konstanz, who made a visit to Chemnitz University of Technology and gave a lecture on “Pushing the envelope of solid-state NMR: new methods, new applications”.

Pulsed dynamic nuclear polarization

Pulsed dynamic nuclear polarization All spectroscopic methods evolve from continuouswave to pulsed. Magic-angle spinning NMR in combination with DNP has, so far, been an exception. We try to change that by designing microwave pulse sequences.

Amorphous materials and biomineralization

• We use an approach inspired by structure-refinement in X-ray diffraction.
• Due to a colloidal pathway of formation, amorphous calcium carbonate exhibits rigid and mobile environments.

Spin dynamics simulations

• large spin systems, using restricted state spaces
• towards high-field triplet DNP
• pulsed DNP in the steady-state

Weakly folded proteins

The ubiquitin-like modifier FAT10 is prone to precipitation. Stabilization by co-sedimentation with the adapter protein NUB1L enabled the first characterization of the structure of wildtype FAT10.